When I first began researching my husband John’s Parkinson’s diagnosis, I never expected to find myself deep in the world of microbiome science. But time and time again, the research pointed me back to the gut—its delicate balance of bacteria, its role in digestion, and its powerful influence on brain health.
One of the most eye-opening discoveries? The role of Helicobacter pylori (H. pylori) and endotoxins in neuroinflammation. Scientists have long suspected that the gut-brain connection plays a role in neurodegenerative diseases, but the deeper I looked, the clearer it became: digestion, stomach acid, and even chronic stress may be affecting brain health in ways we’re only beginning to understand.
For years, Parkinson’s disease has been thought of primarily as a disorder of the nervous system, characterized by the loss of dopamine-producing neurons in the brain. But what if the earliest signs of Parkinson’s actually begin in the gut? Emerging research suggests that disruptions in digestion, chronic inflammation, and gut dysbiosis could play a significant role in the progression of neurological conditions—including Parkinson’s.
The Gut-Brain-Stress Cycle: A Missing Piece of the Puzzle?
Many people think of H. pylori as just a bacteria that causes ulcers, but it’s far more than that. It thrives in a low-acid environment, meaning that people with reduced stomach acid—a common side effect of chronic stress—are more susceptible to infection. And once H. pylori takes hold, it can trigger a cascade of effects that may contribute to conditions like Parkinson’s.
So, how does this all connect? Let’s break it down.
Chronic Stress Suppresses Stomach Acid
Stress is one of the most overlooked factors in digestive health. When we experience chronic stress, our bodies produce elevated levels of cortisol, the “fight or flight” hormone. While cortisol plays an important role in survival, prolonged stress responses can wreak havoc on the digestive system.
One of cortisol’s lesser-known effects is its ability to suppress stomach acid (hydrochloric acid or HCl). While we often hear about problems caused by too much stomach acid—think acid reflux—low stomach acid is an even bigger issue for many people. Without enough stomach acid:
Proteins don’t break down properly, leading to digestive discomfort and nutrient deficiencies.
Pathogens like H. pylori can survive and thrive, creating an environment ripe for infection.
The gut lining becomes more vulnerable, increasing the risk of inflammation and leaky gut.
H. pylori Infection & Low Stomach Acid Create a Vicious Cycle
Under normal conditions, stomach acid serves as the body’s first line of defense against harmful microbes. But when stomach acid levels drop—due to stress, diet, or aging—H. pylori finds an ideal environment to multiply.
This bacterium is particularly insidious because it has evolved ways to neutralize stomach acid even further, allowing it to colonize the stomach lining. Over time, H. pylori can cause gastritis, ulcers, and increased intestinal permeability, contributing to systemic inflammation.
But what’s even more concerning is its ability to release endotoxins, specifically lipopolysaccharides (LPS), which have profound effects on brain health. (See my previous post on endotoxins)
Endotoxins & Neuroinflammation: A Link to Parkinson’s?
Once H. pylori establishes itself, it releases LPS, toxic compounds that can enter the bloodstream and trigger inflammation throughout the body. When these endotoxins reach the brain, they can:
Activate microglia, the brain’s immune cells, leading to chronic neuroinflammation.
Disrupt dopamine production, impairing motor function and cognition.
Damage the gut lining, making it easier for more toxins to enter circulation—a condition often referred to as “leaky gut.”
Neuroinflammation is a key factor in Parkinson’s and other neurodegenerative diseases. Researchers have even found higher levels of LPS in the brains of individuals with Parkinson’s, suggesting a strong link between gut infections and neurological decline.
The Gut-Brain Connection & The Vagus Nerve
How do these inflammatory signals travel from the gut to the brain? One of the primary highways for this communication is the vagus nerve. The vagus nerve serves as a direct line between the gut and the brain, constantly relaying information about digestion, immune responses, and microbial balance. When the gut is inflamed or disrupted by pathogens like H. pylori, the vagus nerve transmits distress signals to the brain, potentially worsening neurodegenerative processes.
This could explain why early symptoms of Parkinson’s—such as constipation and digestive issues—often appear years or even decades before motor symptoms. The gut may, in fact, be the earliest battleground for neurological health.
Nutrient Malabsorption & The Brain
Beyond inflammation, H. pylori and low stomach acid also contribute to nutrient deficiencies—a critical but often overlooked factor in brain health.
Vitamin B12 Deficiency – B12 is essential for nerve function and cognitive clarity. Low levels have been linked to brain fog, memory issues, and neurodegeneration.
Magnesium & Zinc Deficiency – Both minerals play a role in neurotransmitter function and stress regulation.
Amino Acids & Dopamine Production – Poor digestion means reduced absorption of amino acids, which are the building blocks of dopamine and serotonin—key neurotransmitters involved in mood, movement, and motivation.
Testing & A Holistic Approach to Healing
One of the most important takeaways from Coach Debbie Potts’ video is the need for testing, not guessing. Many people struggle with digestive issues for years without knowing if H. pylori or low stomach acid is playing a role. Simple tests—such as stool tests, breath tests, or stomach acid tests—can provide valuable insights into gut health.
From there, taking a holistic approach is key. Some effective strategies include:
Stress Reduction Techniques – Deep breathing, meditation, and mindfulness can help regulate cortisol levels and improve digestion.
Digestive Support – Bitters, apple cider vinegar, and digestive enzymes can aid stomach acid production.
Probiotics & Microbiome Support – Beneficial bacteria help crowd out harmful pathogens and restore gut balance.
Whole Foods & Anti-Inflammatory Diet – Nutrient-dense foods rich in polyphenols, omega-3s, and antioxidants can help combat inflammation.
A Deeper Dive with Coach Debbie Potts
In her latest video, Coach Debbie Potts shares insights into how gut health, stress, and digestion play a role in cognitive function and overall health.
Debbie’s insights emphasize a holistic, systems-based approach to healing—one that looks beyond symptoms and addresses the root causes of gut-brain dysfunction.
Final Thoughts
The more we understand the gut-brain connection, the more empowered we become in our health journey. If you or a loved one are navigating Parkinson’s—or simply looking to protect cognitive function—addressing gut health is a critical piece of the puzzle.
The journey to healing often starts in unexpected places, and for many, that journey begins in the gut.
What are your thoughts on the gut-brain connection? Have you explored digestive health as part of your wellness journey? Let’s continue the conversation.
With gratitude,
